Mina Emad Adly Elias Makarious <br/><br/>
Synthesis and anticancer activity of certain quinoline and 1,8-naphthyridine derivatives /  
 تشييد و دراسة النشاط المضاد للأورام لبعض مشتقات الكينولين و 8,1-النافثريدين 
Mina Emad Adly Elias Makarious ; Supervised Omneya Mahmoud Khalil , Ehab Mohamed Abdelmoneim Gedawy , Afaf Ali Atia Elmalah 
 - Cairo :   Mina Emad Adly Elias Makarious ,   2019 
 - 136 P. :   charts ;   25cm 
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Organic Chemistry 
<br/><br/> This thesis includes four chapters. The first chapter is an introduction which includes a survey about topoisomerase enzymes, their inhibitors and the synthesis of quinolines and 1,8-naphthyridine derivatives. The second chapter shows the objectives of the work and the designed schemes required for the preparation of the target compounds. The third chapter includes the theoretical discussion of the experimental work, cytotoxic activity, cell cycle analysis and topoisomerase II inhibitory activity. Furthermore, it discusses the molecular modeling for all synthesized compounds and the standard topoisomerase II inhibitor merbarone. The fourth chapter studies the experimental part of this thesis which contains the procedures used for the synthesis of the starting compounds, the target compounds and intermediates as well as the physical properties of the synthesized compounds, elemental analysis and spectral data. In addition, it demonstrates the results and procedures for the cytotoxic activity, cell cycle analysis and topoisomerase II inhibitory activity as well as the molecular modeling study 
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<br/><br/><label>Subjects--Index Terms: </label>1,8-naphthyridine derivatives Anticancer Activity  Certain quinoline