TY  - BOOK
AU  - Noura Ragab Abdelazem Abdelrahman
AU  - Laila Ahmed Rashed , 
AU  - Maha Fathy Elmasry , 
AU  - Maha Mohamed Salah Eldin , 
TI  - Association between long noncoding RNA taurine up regulated gene 1(TUG1) and microRNA-377 in vitiligo / 
PY  - 2019///
CY  - Cairo : 
PB  - Noura Ragab Abdelazem Abdelrahman , 
KW  - miRNA377
KW  - TUG1
KW  - Vitiligo
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Medical Biochemistry; Issued also as CD
N2  - Background: Vitiligo is the commonest hypopigmented skin disorder. Taurine upregulated gene1(TUG1), one of Long noncoding RNAs (LncRNA) that  plays a role in melanogenesis. microRNA-377 (miRNA-377) is a conserved non-coding RNA that regulates angiogenesis and promotes oxidative stress. Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily. PPARÞ activators stimulate melanogenesis. Interleukin-17(IL17) has been implicated in the pathogenesis of several immunological diseases. Aim: This work aimed to detect the expression levels of TUG1, miRNA-377, PPARÞ and IL-17 among vitiligo subjects and to investigate their possible role in the pathogenesis of vitiligo. Methods: This study was conducted on 30 healthy control and 30 vitiligo patients. TUG1 and miRNA-377 were detected in serum by real- time-PCR, Also PPARÞ and IL-17 were assessed in tissue by Real-time PCR. Results: TUG1and PPARÞ level was significantly down regulated in vitiligo group compared to control group, on the other hand miRNA-377 and IL-17 was significantly up regulated in vitiligo group compared to control group
ER  -