TY  - BOOK
AU  - Doaa Mohamed Hassan
AU  - Ahmed Ibrahim Amin , 
AU  - Ismail Abdelshafy Abdelhamid , 
AU  - Samar Kamal Kassim , 
TI  - Biochemical studies of hippocampal gene expression of brain toll like receptor in diabetic&derived neurotrophic factor rats exposed to chronic restraint stress : : Effect of antidepressant drugs / 
PY  - 2019///
CY  - Cairo : 
PB  - Doaa Mohamed Hassan , 
KW  - BDNF
KW  - Fluoxetine
KW  - TLR4
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - This work investigates the alteration in gene expression of BDNF and TLR4 in the hippocampus of diabetic rats and non-diabetic maleWistar rats exposed to chronic restraint stress.Study included eight groups were used. fourgroups include: 1-Naïve rats, 2-non-diabetic CRS vehicle treated, 3-non-diabetic CRS fluoxetine treated&4- non-diabetic CRS imipramine treated; the same four groups with diabetic rats. Laboratory investigation were determined by using semi quantitative RT-PCR&ELISA. Diabetic rats & rats expose to CRS show significant decrease in gene expression & protein of BDNF with significant increase in in gene expression & protein of TLR4. It is concluded that BDNF & TLR genes has effective role with inflammatory state &stress and act in contrary manner and the preferable of fluoxetine over imipramine
UR  - http://172.23.153.220/th.pdf
ER  -