TY  - BOOK
AU  - Muhammad Hani Muhammad 
AU  - Ayman Aboelenein Rizk  , 
AU  - Safwat Wadea Gerges , 
AU  - Waleed Ahmed Badawy , 
TI  - The possible prophylactic role of l-carnitine on induced renal ischemia-reperfusion injury in adult male albino rat : : A histological, biochemical and immunohistochemical study / 
PY  - 2019///
CY  - Cairo : 
PB  - Muhammad Hani Muhammad  , 
KW  - Ischemia
KW  - L-carnitine
KW  - Reperfusion
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Anatomy; Issued also as CD
N2  - Renal ischemia reperfusion injury can lead to organ dysfunction or failure and is a serious clinical problem during renal transplantation , shock or major surgery. Aim of the work: Was to investigate the possible protective role L-carnitine versus induced renal ischemia reperfusion injury in adult male albino rat using histological, biochemical and immunohistochemical  methods. Material and methods: This study was conducted on 50 adult male albino rats were divided into 3 groups: control group, induced ischemia reperfusion group and L-carnitine pretreated groups (before  induction of ischemia).All these groups underwent histological study using Hx.and E stain, PAS stain and caspase-3 stain.Biochemical study was done using blood samples to detect the serum urea and creatinine levels.Histochemical study was done todetect the levels of MDA ,SOD and GSH .Histomorphometric study was done to detect the mean optical density of PAS stain and the mean area percentage of caspase- 3immunoexpression.All these investigations underwent statistical analysis Results: the present study has found that the pretreatment with L-carnitine has improved the renal functions,decreased the MDA levels,increased SOD and GSH levels with  restoring the normal renal arcitechture with reduced areas of apoptotic cells, blood extravasation,pyknotic nuclei and vacuolated cells
ER  -