TY  - BOOK
AU  - Ayman Abdelaziz Ibrahim Abdelaziz Eltantawy
AU  - Esmat A. Shaaban , 
AU  - Mohammed F. Elyamany , 
TI  - The possible pharmacological effect of a certain antioxidant against gamma radiation-inducedtesticular toxicity in rats / 
PY  - 2019///
CY  - Cairo : 
PB  - Ayman Abdelaziz Ibrahim Abdelaziz Eltantawy , 
KW  - Apoptosis
KW  - Mitochondria-targeted antioxidant
KW  - MitoQ
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Aims: The deleterious effect of gamma radiation on testicular tissue is a challenging problem in nuclear medicine. This study investigated the potential radioprotective and curative effects of Mitoquinol (MitoQ), a mitochondria-targeted antioxidant, against testicular damage induced by gamma irradiation in rats. Main methods: firstly, a pilot study was conducted to select the most effective dose of MitoQ via estimation of sperm features, testicular caspase-3 along with histological evaluation. The investigated doses were (0.5, 1, 2, 5 & 10) mg/kg/day; i.p. for seven days before gamma irradiation (5 Gray as a single dose) and the most effective dose was 2 mg/kg/day. Then, main study was performed where rats were allocated into five groups. The first group served as the control, the second group received MitoQ (2 mg/kg/day; i.p.) for seven days, the third group was exposed to gamma radiation (5 Gray as a single dose), the fourth group received MitoQ prior to irradiation and the last group received MitoQ after irradiation
UR  - http://172.23.153.220/th.pdf
ER  -