TY  - BOOK
AU  - Ibrahim Mohamed Ibrahim Naguib
AU  - Iman Mohamed Hamza , 
AU  - Waleed Fouad Fathalah , 
AU  - Walied Khalid Alhossary , 
TI  - A randomized controlled study comparing fluoroquinolone based sequential therapy versus clarithromycin triple therapy for the eradication of helicobacter pylori in Egypt / 
PY  - 2019///
CY  - Cairo : 
PB  - Ibrahim Mohamed Ibrahim Naguib , 
KW  - Fluoroquinolone sequential therapy
KW  - Helicobacterpylori
KW  - Triple therapy
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Tropical Medicine; Issued also as CD
N2  - Aim: This study aimed at evaluating Moxifloxacin-based sequential therapy VS. Clarithromycin triple therapy as first line regimens for eradication of H-pylori.  Methods: In this randomized clinical trial, 93 HP infected patients were randomly divided into two groups. Moxifloxacin based sequential regimen (group A); omeprazole and amoxicillin for 7 days followed by omeprazole, metronidazole and moxifloxacin for 7days.Clarithromycin based triple regimen (group B): omeprazole, amoxicillin and clarithromycin for 14days. Stool antigen test was used to evaluate HP eradication 6 weeks after the end of treatment.Compliance, drug side effects and dypepsia improvement were secondary outcomes.Results: Per protocol eradication rates of group A and B were 79.5% and 86% respectively. By intention to treat analysis, group A had an eradication rate of 68.9% while group B had an eradication rate of 77.1%.  Conclusion: In this study,Triple therapy was more effective than moxifloxacin-sequential therapy. However, the difference was statistically insignificant. Studies with larger sample size are needed
UR  - http://172.23.153.220/th.pdf
ER  -