Serum intestinal fatty acid binding protein as a marker for diagnosis of necrotizing enterocolits in preterm infants /
دور البروتين الملازم للأحماض الدهنية المعوية بمصل الدم كدلالة لتشخيص مرض التهاب الأمعاء الناخر في الأطفال المبتسرين
Omar Mohammed Ezz Eldin Sayed ; Supervised Hala Mufeed Said , Sherif Elanwary Abdelmonem , Rabab Elsayed Elhawary
- Cairo : Omar Mohammed Ezz Eldin Sayed , 2019
- 121 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease with high morbidity and mortality, characterized by intestinal cell damage and inflammation.NEC results from combination of several factors, including genetic predisposition, intestinal immaturity, excessive intestinal inammatory response, and inappropriate microbial colonization.Because NEC is characterized by loss of bowel wall integrity, intestinal fatty acid-binding protein (I-FABP) is one of the more promising biomarkers.This small cytosolic protein, located mainly in enterocytes of the small intestine, is released into the blood stream after cell disruption.In this study, we aimed to investigate the value of serum I-FABP in early diagnosis and predicting severity of NEC