Comparative study between nebulized and metered dose inhaled salbutamol in a group of Egyptian asthmatic children regarding effect on pulmonary function tests /
دراسة مقارنة بين مفعول استنشاق السالبيوتامول عن طريق جهاز الاستنشاق أو عن طريق البخاخة ذات الجرعة القياسية على وظائف الرئة في مجموعة من الأطفال المصريين المصابين بحساسية الصدر
Ahmed Tawfek Abdellatif Zedan ; Supervised Iman Hassan Draz , Christine William Shaker Basanti , Nevine Ramzy Elbaroudy
- Cairo : Ahmed Tawfek Abdellatif Zedan , 2019
- 138 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Inhaled salbutamol is short B2 agonist act on B2receptors in airways causing relaxation of bronchial smooth muscle leading to bronchodilation. The main methods of administration are by inhalation or nebulization.This is prospective, randomized study aimed to compare effectiveness of nebulized salbutamol inhalation versus metered dose salbutamol inhaler as regard pulmonary function tests in a group of asthmatic Egyptian children. For this purpose, 100 children asthmatic children aged 6-14 years were recruited from Pulmonology and Allergy clinic of Specialized Children Hospital, Cairo University , devided into 2 groups : one group received Metered dose inhaler salbutamol via aerochamber and other group received nebulized salbutamol and comparing between the two groups by spirometry parameters which was done before and 20 minutes after inhalation. When comparing both groups` results, there was significant lower post treatment values in nebulizer group in FEV1 post treatment (90.58 ± 11.74) compared to )96.23± 13.09( in inhaler group (p= 0.025). Also mean FVC post )86.5 ± 12.09( in nebulizer group, which was significantly lower than in mean FVC post treatment in inhaler group; )95.46 ± 10.65( (p value was <0.001). However, the FEV1/FVC in nebulizer group post treatment was (105.03 ±9.90) which is significantly higher than that of inhaler group (100.6 ± 10.1), this difference was statistically significant (p=0.032)