Hepatotoxicity effect of short-term bradykinin potentiating factor in cholestatic rats /
تأثير السمية الكبدية قصيرة المدى للعامل المحفز للبراديكينين فى الجرذان المصابة بالركود الصفراوى
Hanan Ahmed Mohamed Issa ; Supervised Sohair Ramadan Fahmy , Amel Mahmoud Soliman
- Cairo : Hanan Ahmed Mohamed Issa , 2019
- 176 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Zoology
Cholestatic liver injury is one of the major causative factors for the development of liver fibrosis and cirrhosis. Drug-induced hepatotoxicity is responsible for a variety of pathological effects on the liver. It was reported that hepatotoxicity induced by angiotensin converting enzyme inhibitors (ACEIs) is cholestasis mediated hepatitis. Bradykinin-potentiating factor (BPF) is one of the natural ACEIs. Although prolonged treatment with ACEIs provides protection against liver injury, the effect of short-term treatment with ACEIs has not been fully elucidated before.Thereby, the present study sought to determine if transient ACE inhibition may exacerbate the hepatotoxicity caused by bile duct ligation (BDL) in rats.Twenty one Wistar rats were divided into 3 groups (7 rats/group) Sham-operated group, BDL rats, and BDL rats treated for shortterm with BPF (1 og/kg body weight) day after day for one week. The result revealed that There was a significant increase in liver enzymes, bilirubin levels, and oxidative stress in the BDL group after treatment with BPF as compared to BDL group.It was found overexpression of ACE1 gene in BDL group compared to BPF and Sham-operated control group. Histopathological examination of liver treated with BPF showed severe degeneration hepatic architecture and hepatocytes as compared to BDL group. Collagen deposition increased after BPF treatment as compared to BDL groups