TY  - BOOK
AU  - Asmaa Mohamed Atef Abdelrahman
AU  - Emad Nabil Ebeid , 
AU  - Eman Omar Rasekh , 
AU  - Nayera Hamdy Elshakankiry , 
TI  - Cytokine receptor like factor 2 (CRLF2)- overexpressing pediatric Precursor B- acute lymphoblastic leukemia : : An approach towards individualized therapy / 
PY  - 2020///
CY  - Cairo : 
PB  - Asmaa Mohamed Atef Abdelrahman , 
KW  - B cell precursor ALL
KW  - CRLF2
KW  - Philadelphia-like ALL
N1  - Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology; Issued also as CD
N2  - Introduction: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a neoplastic proliferation of lymphoblasts that has a gene expression profile similar to that of BCR-ABL1 positive B-ALL, but lacks the disease-defining Philadelphia chromosome. Growing evidence has proved that alterations in the cytokine receptor-like factor 2 gene (CRLF2)that result in CRLF2 overexpression associates with poor treatment outcomes thus highlighting a potentially important oncogenic mechanism in a subset of patients. The significant association of CRLF2 overexpression with JAK2 mutation suggests that these patients may benefit from future kinase inhibitor approaches. In addition, cell surface-expressed CRLF2 itself may be a potential target for anti-CRLF2 antibody based therapies
UR  - http://172.23.153.220/th.pdf
ER  -