TY - BOOK AU - Huda Ibrahim Suliman Hegazy AU - Doaa Mohammed Ghaith , AU - Hala Mohammed Fouad , AU - Hebat Allah Fadel Elgebaly , TI - Role of serum (1,3)-Ý-D-glucan assay in early diagnosis of invasive f ungal infection in pediatric intensive care unit / PY - 2020/// CY - Cairo : PB - Huda Ibrahim Suliman Hegazy , KW - Children KW - Mortality KW - Pediatric intensie care unit (PICU) N1 - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD N2 - This study shows that critically ill children are at high risk of developing invasive fungal infection in a pediatric intensive care unit. Delaying the appropriate antifungal treatment of Invasive Candidiasis (IC) while awaiting blood culture results has been associated with increased hospital mortality. The Candida score is a useful tool to differentiate critically ill patients, who would benefit from early antifungal treatment (score >3), from those in whom invasive candidiasis is highly improbable (score {u2264}3). One of the developed biomarkers is (1,3)-Ý-D-Glucan (BG), which is a major cell wall component of almost all fungi except for Zygomycetes and Cryptococcus species. Various studies measured different sensitivity and specificity of (1,3)-Ý-D-Glucan (BG)substance ER -