Hussein Ahmed Ali Elmahdy <br/><br/>
MicroRNA-215 as a diagnostic marker in Egyptian patients with hepatocellular carcinoma /  
 تقييم الحمض النووى الريبوزى المتناهى الصغر 215 كدلالة تشخيصية فى المرضى المصريين المصابين بسرطان الكبد  
Hussein Ahmed Ali Elmahdy ; Supervised Ismail Abdelshafy Abdelhamid , Mona Mahmoud Hassouna , Ahmed Ibrahim Amen 
 - Cairo :   Hussein Ahmed Ali Elmahdy ,   2020 
 - 142 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry 
<br/><br/> Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and the third leading cause of cancer-related death. In Egypt, 80% of the patients with hepatocellular carcinoma have underling hepatitis C. MicroRNAs are reported as a group of small non-coding RNAs and aberrant miRNA expression has been reported in HCC patients or cell lines. We aimed to assess diagnostic value of plasma MicroRNA-215 in patients with hepatocellular carcinoma. Methods: A prospective study included 195 subjects divided into 3 groups: healthy controls (group I), Cirrhotic patients (group II), and patients with HCC (group III); all cases were subjected to thorough clinical examination, radiological and laboratory investigations which included quantification of miR-215 by Real- Time qPCR In conclusion, Plasma level of miR-215 might be considered as potential biomarker for diagnosis of HCC. Moreover, miR-215 combined with AFP can be used as a diagnostic biomarker, for early detection of HCC 
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<br/><br/><label>Subjects--Index Terms: </label>Chronic hepatitis C virus (chronic HCV)  Hepatocellular carcinoma (HCC),  MicroRNA-215 (miR-215)