TY  - BOOK
AU  - Hussein Ahmed Ali Elmahdy
AU  - Ahmed Ibrahim Amen , 
AU  - Ismail Abdelshafy Abdelhamid , 
AU  - Mona Mahmoud Hassouna , 
TI  - MicroRNA-215 as a diagnostic marker in Egyptian patients with hepatocellular carcinoma / 
PY  - 2020///
CY  - Cairo : 
PB  - Hussein Ahmed Ali Elmahdy , 
KW  - Chronic hepatitis C virus (chronic HCV)
KW  - Hepatocellular carcinoma (HCC),
KW  - MicroRNA-215 (miR-215)
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry; Issued also as CD
N2  - Hepatocellular carcinoma (HCC) is the fifth most commonly diagnosed cancer worldwide and the third leading cause of cancer-related death. In Egypt, 80% of the patients with hepatocellular carcinoma have underling hepatitis C. MicroRNAs are reported as a group of small non-coding RNAs and aberrant miRNA expression has been reported in HCC patients or cell lines. We aimed to assess diagnostic value of plasma MicroRNA-215 in patients with hepatocellular carcinoma. Methods: A prospective study included 195 subjects divided into 3 groups: healthy controls (group I), Cirrhotic patients (group II), and patients with HCC (group III); all cases were subjected to thorough clinical examination, radiological and laboratory investigations which included quantification of miR-215 by Real- Time qPCR In conclusion, Plasma level of miR-215 might be considered as potential biomarker for diagnosis of HCC. Moreover, miR-215 combined with AFP can be used as a diagnostic biomarker, for early detection of HCC
UR  - http://172.23.153.220/th.pdf
ER  -