Role of preoperative tranexamic acid in decreasing blood loss in preeclamptic patients undergoing cesarean section : Randomized controlled trial /
تأثير حمض الترانيكساميك فى تقليل فقدان الدم قبل الجراحة فى الولادة القيصرية لمرضى تسمم الحمل : دراسة عشوائية
Noran Mohamed Amin Abdelhakim ; Supervised Reda Ismail Riad , Ahmed Hussein Ali Elsawaf , Mahmoud Mohamed Abdelhamid Soliman
- Cairo : Noran Mohamed Amin Abdelhakim , 2020
- 75 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine- Department of Gynecology and Obstetrics
Objective: To study the efficacy and safety of preoperative IV TA to reduce blood loss during and after elective or emergency lower-segment CS in preeclamptic patients. Methods:A double-blind, randomized placebocontrolledstudy was undertaken of preeclamptic singleton women undergoing elective or emergency lower-segment CS atKasrAlainy during the period from September 2019 toFebruary 2020. Patients were randomly assigned (1:1) using computer-generated random numbers to receive either 1 g TA or 5% glucose over 15 minutes before surgery. Preoperative and postoperative complete blood count, hematocrit values, and maternal weight were used to calculate the estimated blood loss (EBL) during CS. Main outcome measures: EBL during and after CS in preeclamptic patients. Results: Analyses included 35 women in each group. Mean EBL was significantly higher in the placebo group (819 ± 172 mL) than in the TA group(383.3 ± 140.7 mL)(P < 0.001). Mean EBL was significantly lower in mild than in severe preeclampsia.There were no reports of thromboembolic events postoperatively. Conclusions: Preoperative administrationof TA in preeclampticpatients safely and effectively reduces blood loss during elective or emergency lower-segment CS without any recorded adverse effects. Blood loss is significantly lower in mild than severe preeclampsia after TA administration