Aya Mohamed Abdelghany Ahmed <br/><br/>
Development of biodegradable polymeric nanocapsules as a drug delivery system targeting Helicobacter pylori /  
 تطوير كبسولات بوليمارية متناهية الصغر قابلة للتحلل البيولوجى لنقل الدواء الذى يستهدف الميكروب الحلزونى  
Aya Mohamed Abdelghany Ahmed ; Supervised Mohamed Ali Eldesouky ,Mohamed Abbas Shemis   
 - Cairo :   Aya Mohamed Abdelghany Ahmed ,   2020 
 - 95 P. :   charts , facsimiles ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Science - Department of Biochemistry  
<br/><br/> In this study we used double emulsion technique to prepare spherical shaped polymeric nanocapsules composed of amoxicillin trihydrate as the core substance and a biodegradabe biocompatible poly (-caprolactone) as the shell material. The hydrodynamic diameter of the prepared nanocapsules was 287 ± 8 nm with positive zeta potential. In vitro release study indicated that the polymeric nanocapsules showed the least release at pH 1.2 simulating the gastric fluid while increasing release at pH 7.0 where the H. pylori resides. The in vitro antibacterial assay showed better efficiency for Amoxicillin nanocapsules than the free drug. Cytotoxicity studies showed least cytotoxicity for the polymeric nanocapsules in comparison to the amoxicillin 
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<br/><br/><label>Subjects--Index Terms: </label>Double emulsion   H. pylori Polymeric nanocapsules