Lamiaa Nabih Helal Elfadali <br/><br/>
Nucleophosmin mutations in De novo adult acute myeloid leukemia and its prognostic impact /  
 دراسة تكرار طفرة جين النيوكليوفوزمين فى حالات سرطان الدم الميلودى الحاد الجديدة لدى البالغين 
Lamiaa Nabih Helal Elfadali ; Supervised Khaled Mostafa Aboulenein , Naglaa Mostafa Hassan Ahmed , Raafat Mohammad Abdelfattah 
 - Cairo :   Lamiaa Nabih Helal Elfadali ,   2020 
 - 143 P. :   charts , facsimiles ;   25cm  
<br/><br/>Thesis (Ph.D.) - Cairo University - National Cancer Institute - Department of Clinical Pathology 
<br/><br/> Aim:To evaluate the frequency of NPM mutation A in denovo adult AML and to evaluate its relation with clinical and laboratory parameters and with response to treatment. Patients and Methods: 89 patients were included in our study, taking BM samples, RNA extraction and quantitative RT-PCR were done to detect the frequency of NPM1 mutation A. Results:We found NPM1 mutation in 33/89 (37.1) AML patients of which NPM mutation A was found in 6/33 (18.1%) NPM mutated AML patients and was 6/89 (6.7%) of AML patients. 24/33 (72.7%) NPM mutated patients were died before day 28 of treatment. 9/33 (27.3%) NPM mutant patients achieved CR. 5/6 (83.3%) NPM mutation A patients  died before D28 of treatment and 1/6 (6.7%) NPM mutation A patient achieve CR with no statistically significance. Conclusions:We found that frequency of NPM gene mutation was 37% of AML patients and NPM gene mutation A was 18% of NPM1 mutation and 6.7 of AML patients  
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Activities of daily living (ADL)  Acute myeloid leukemia   Nucleophosmin gene mutation