Evalution of individuals with sickle cell trait for early renal impairment /
تقييم الضعف الكلوي المبكر فى الاشخاص الحاملى لجين الخلايا المنجليه
Asmaa Mohammed Elaraby Abdelgawad ; Supervised Mona Hassan Eltagui , Niveen M. Salama , Hanan Ali Ahmed Madani
- Cairo : Asmaa Mohammed Elaraby Abdelgawad , 2020
- 136 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics
Sickle cell trait (SCT) is one of the heterozygous forms of sickle cell disease (SCD). Although SCD has become a recognized etiology of chronic kidney disease (CKD), SCT was until recently believed to be a benign carrier state with little or no effect on the health of affected individuals.Serum Cystatin C has been proposed to be a promising marker which can help detect early nephropathy. Aim of work: To evaluate renal impairment in SCT patients and to assess the value of serum Cystatin C as an early marker for diagnosis of such impairment. Patients and methods: This was a cross sectional case control study included 50 Egyptian individuals previously diagnosed as SCT compared with 30 age & sex matched healthy individuals as a control which were recruited from the same study sites.Results: The present study show that 12 cases had renal symptoms.There was statistically significant difference between cases & control groups in serum urea & serum creatinine with P value = (0.0109 & 0.005).There was statistically significant difference between cases & controls as regarding urinary microalbumin& urinary A/C ratio with p value = (0.001, < 0.001). There was no statistically significant difference in cystatin c level between cases & controls. Also there was significant positive correlation between serum cystatin c and serum urea level with p-value = 0.037 and between hemoglobin and hemoglobin S level with p-value =0.014