TY  - BOOK
AU  - Asmaa Mohammed Elaraby Abdelgawad
AU  - Hanan Ali Ahmed Madani , 
AU  - Mona Hassan Eltagui , 
AU  - Niveen M. Salama , 
TI  - Evalution of individuals with sickle cell trait for early renal impairment / 
PY  - 2020///
CY  - Cairo : 
PB  - Asmaa Mohammed Elaraby Abdelgawad , 
KW  - Renal impairment
KW  - Sickle cell disease
KW  - Sickle cell trait
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Sickle cell trait (SCT) is one of the heterozygous forms of sickle cell disease (SCD). Although SCD has become a recognized etiology of chronic kidney disease (CKD), SCT was until recently believed to be a benign carrier state with little or no effect on the health of affected individuals.Serum Cystatin C has been proposed to be a promising marker which can help detect early nephropathy. Aim of work: To evaluate renal impairment in SCT patients and to assess the value of serum Cystatin C as an early marker for diagnosis of such impairment. Patients and methods: This was a cross sectional case control study included 50 Egyptian individuals previously diagnosed as SCT compared with 30 age & sex matched healthy individuals as a control which were recruited from the same study sites.Results: The present study show that 12 cases had renal symptoms.There was statistically significant difference between cases & control groups in serum urea & serum creatinine with P value = (0.0109 & 0.005).There was statistically significant difference between cases & controls as regarding urinary microalbumin& urinary A/C ratio with p value = (0.001, < 0.001). There was no statistically significant difference in cystatin c level between cases & controls. Also there was significant positive correlation between serum cystatin c and serum urea level with p-value = 0.037 and between hemoglobin and hemoglobin S level with p-value =0.014
ER  -