TY  - BOOK
AU  - Marwa Farrag Abdelaziz 
AU  - Mina Ibrahim Tadros , 
AU  - Mohamed Ahmed Elnabarawi , 
AU  - Soha Abdelfattah Elsayed , 
TI  - A pharmaceutical study on certain gastroretentive devices of an alpha receptor blocker / 
PY  - 2020///
CY  - Cairo : 
PB  - Marwa Farrag Abdelaziz , 
KW  - Alfuzosin hydrochloride (ALF)
KW  - Alpha receptor blocker
KW  - Certain gastroretentive devices
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - The current work aimed to improve the oral bioavailability of alfuzosin hydrochloride (ALF),  sustain the rate of its release and deliver it to the main site of absorption via optimization of low- density gastroretentive drug delivery systems.  The work in this thesis is divided into:  Chapter 1: Formulation & evaluation of alfuzosin hydrochloride-loaded floating tablets utilizing  sublimation technique.  Chapter 2: Formulation & evaluation of alfuzosin hydrochloride-loaded low-density gastroretentive  sponges.  Chapter 1: Formulation & evaluation of alfuzosin hydrochloride-loaded floating tablets  utilizing sublimation technique.  Gastroretentive tablets were prepared, according to a 3 1{u00D7} 2 1{u00D7}4 1 full factorial design, by direct  compression method followed by a sublimation process. HPMC K4M, PEO WSR N 60K or  carbopol 934 were used as release retarding polymers. Camphor or menthol were used as  sublimable agents, each in a concentration of 3%, 6%, 9% or 12% w/w. FTIR and DSC were  performed to check drug-excipients compatibility. The developed tablets were evaluated regarding  their appearance, hardness, friability, density, floating behavior as well as in vitro ALF release. The  optimized formula was selected, based on the desirability value, and morphologically evaluated via  SEM. In addition, in vivo monitoring of its gastroretentivity was performed after loading with  magnetite via MRI
ER  -