TY  - BOOK
AU  - Salah Abdullah Ahmed Abdo
AU  - Mahmoud Khattab , 
AU  - Rania Mohsen Abdelsalam , 
AU  - Walaa Wadie , 
TI  - Effect of antidepressants on experimentally induced colitis in normal and ovariectomized depressed rats / 
PY  - 2020///
CY  - Cairo : 
PB  - Salah Abdullah Ahmed Abdo , 
KW  - Colitis
KW  - Depression
KW  - Escitalopram
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Escitalopram, a drug of first-choice in the treatment of depression, was recently  shown to possess an anti-inflammatory activity. The aim of the present study was to elucidate the effect of escitalopram on peripheral inflammatory cascades in  iodoacetamide-induced colitis in normal and ovariectomized rats. Moreover, the involvement of Ü-7 nicotinic acetylcholine receptor in mediating the anti-colitic  effect of escitalopram was examined using a nicotinic receptor antagonist  methyllycaconitine citrate. Colitis was induced by intracolonic instillation of  iodoacetamide. Escitalopram (10 mg/kg) was given once daily for one week.  Treatment with escitalopram improved colitis as indicated by a decrease in weight  loss, colon mass index, ulcerative area and total histology score. Moreover, it  reversed iodoacetamide-induced rise in colonic myeloperoxidase activity, tumor  necrosis factor-{uF061} level and corticotropin releasing hormone content. Escitalopram  was also effective in normalizing the expression of tight junction proteins in  colonic tissues. These potential effects of escitalopram were noticed in the  presence of methyllycaconitine. The present study revealed the potential anti- inflammatory effect of escitalopram against iodoacetamide-induced colitis in  normal and ovariectomized rats
UR  - http://172.23.153.220/th.pdf
ER  -