Study on the possible protective effects of some drugs and natural agents on experimentally induced dementia in rats /
دراسة عن امكانية تأثيرات بعض الأدوية والمواد الطبيعية في الخلل المحدث تجريبيا في الجرذان
Nada Gamal Abdelfattah Elsamahy ; Supervised Mohamed T. Abdelaziz , Mohammed F. Elyamany , Mai A. Galal Abdelfattah
- Cairo : Nada Gamal Abdelfattah Elsamahy , 2020
- 168 P . : charts , facsmilies ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology
Dementia is a syndrome of global cognitive decline which intervenes with social and occupational functioning. It is common in the elderly and constitutes one of the largest burdens for individuals and society.The most common types of dementia are Alzheimers disease (AD), caused by neurodegeneration and vascular dementia,caused by cerebrovascular disease. Although the primary cause of AD remains unclear, A and tau protein aggregation, reduced acetylcholine (Ach) as well as glutamate excitotoxicity may be considered principal pathogenic factors. Many studies have speculated that free radicals produced during oxidative stress and/or inflammatory processes are also involved in progression of AD