TY  - BOOK
AU  - Mohamed Tarek Mohamed Elsaid
AU  - Eman Saad Elzanfaly , 
AU  - Hebatallah Ahmed Wagdy , 
AU  - Sawsan Mohamed Amer , 
TI  - Synthesis and analytical application of molecularly imprinted polymer for some fluoroquinolone drugs / 
PY  - 2020///
CY  - Cairo : 
PB  - Mohamed Tarek Mohamed Elsaid , 
KW  - Fluoroquinolone
KW  - Molecularly imprinted polymer (MIP₁)
KW  - Polymers
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Analytical Chemistry; Issued also as CD
N2  - This work is concerned with synthesis and optimization of molecularly imprinted polymer specific for nadifloxacin. First, twelve molecularly imprinted polymers were synthesized and optimized using nadifloxacin as a template with different ratios of methacrylic acid and/or 4-vinyl pyridine as a functional monomers and ethylene glycol dimethacrylate as a cross-linker. The synthesized polymers that showed the best binding behavior were MIP₁(1:4:20) (template: methacrylic acid: ethylene glycol dimethacrylate) and MIP₂(1:2:2:20) (template: methacrylic acid: 4-vinyl pyridine: ethylene glycol dimethacrylate). Using further investigations, MIP₁showed higher binding capacity and selectivity than MIP₂. The solid phase extractionprocedures were optimized using MIP1 as a sorbent.The studied factors were: polymer weight, cartridge capacity, loading, washing and elution solvents, cartridge selectivity and cartridge reusability. The optimum procedures were using: 80 mg polymer, methanol as a loading solvent, water: acetonitrile (80:20; v/v) as a washing solvent and methanol: acetic acid (90:10; v/v) as elution solvent. Then, the optimized cartridge was used for specific extraction of nadifloxacin from real human plasma samples
UR  - http://172.23.153.220/th.pdf
ER  -