TY  - BOOK
AU  - Ramy Loka Nageh
AU  - Amina Abdelsalam Mahmoud , 
AU  - Mai Mohamed Mohamed Abdelsalam , 
AU  - Mona Ahmed Kamel , 
TI  - The prevalence of disease- related complications in Egyptian children and young adults with sickle cell disease receiving hydroxycarbamide / 
PY  - 2020///
CY  - Cairo : 
PB  - Ramy Loka Nageh , 
KW  - Disease related complications
KW  - Egyptian children
KW  - Hydroxycarbamide
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: Although hydroxyurea has an established role in improving laboratory parameters and reducing acute clinical complications, its role in preventing organ damage in SCD is less well defined. Objectives: To assess the prevalence of disease- related complications in Egyptian patients with SCD receiving HU. Materials and Methods: This is a retrospective analytic study carried out on 60 SCD patients who were receiving HU therapy for at least 1 year. Details of HU therapy, clinical and laboratry data before and after HU were recorded. Results: All patients received HU at a starting dose 15 mg/kg/day with a maximum tolerated dose reached 35 mg/kg/day in 2 patients. Mean HU dose was 19 ± 4.9 mg/ kg/day and mean duration of HU treatment was 6.2 years.There was significant reduction in the frequency of vasoocclusive crises per year, frequency of blood transfusion and rate of hospitalization (p{u02C2}0.05). No significant difference was detected before and after using HU as regards the frequency infections, sequestration, aplastic crises, leg ulcers and cardiac complications (p{u02C3}0.05). One patient developed leg ulcers and another one had pulmonary hypertension while on HU. None of the studied patients had evidence of avascular necrosis at starting HU, however, eight (13.3%) patients developed bone changes while on HU. Two (3.4%) patients developed stroke while on HU and they were shifted to chronic transfusion regimen. There were a significant increases in total Hb, and significant decrease in TLC and reticulocytic count (p{u02C2}0.05). A statistically significant improvement of school scores among patients was seen after HU treatment (P=0.025). A marginally significant improvement of quality of life scores was detected among patients after using HU (P=0.05)
ER  -