TY  - BOOK
AU  - Reem Mohamed Galal Yehia
AU  - Hala F. Zaki , 
AU  - Lamiaa Ahmed , 
AU  - Sanaa A. Kenawy , 
TI  - The potential protective effect of certain natural products on carbon tetrachloride - induced hepatotoxicity / 
PY  - 2020///
CY  - Cairo : 
PB  - Reem Mohamed Galal Yehia , 
KW  - Carbon tetrachloride
KW  - Hepatotoxic injury
KW  - Hepatotoxicity
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - Background: Hepatotoxic injury can have several forms including necrosis, steatosis, fibrosis, cirrhosis and carcinoma. The present study was undertaken to investigate the possible protective effects of quercetin (50 mg/kg), lecithin (100 mg/kg) and their combination versus silymarin (100 mg/kg) as a reference standard against carbon tetrachloride-induced hepatotoxicity. Methods: Male Wistar rats were divided into eight groups where CCl4 (0.5 ml/kg; p.o.; twice/week for 4 weeks) was administered to all groups except the first group that served as normal group. The second group received only CCl4 (0.5 ml/kg, p.o.). Group III, IV and V received orally silymarin (100 mg/kg), quercetin (50 mg/kg) and lecithin (100 mg/kg), respectively. Group VI received orally a combination of silymarin (100 mg/kg) and quercetin (50 mg/kg). Group VII received orally a combination of silymarin (100 mg/kg) and lecthin (100 mg/kg) while group VIII received orally a combination of quercetin (50 mg/kg) and lecithin (100 mg/kg). Results: CCl4 caused marked liver damage as manifested by significant increase in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and alpha-feto protein (AFP) serum levels together with decrease in total protein and albumin serum levels. It also resulted in a significant decrease in liver reduced glutathione (GSH) and total antioxidant capacity (TAC) hepatic contents parallel to a significant increase in malondialdehyde (MDA), inducible nitric oxide synthase (iNOS), nitric oxide (NO), tumor necrosis factor-alpha (TNF-Ü)  and hydroxyproline (HP) hepatic contents
UR  - http://172.23.153.220/th.pdf
ER  -