TY  - BOOK
AU  - Raghda Rabe Mohammed Mohammed Hamed
AU  - Mohamed Ahmed Elnabarawi , 
AU  - Mohamed Farid Elmiligi , 
AU  - Sally Adel Abdelhalim , 
TI  - Formulation and evaluation of a model drug in certain ear drug delivery systems / 
PY  - 2020///
CY  - Cairo : 
PB  - Raghda Rabe Mohammed Mohammed Hamed , 
KW  - Cinnarizine
KW  - Phosphatidylcholine
KW  - Soya phosphatidylcholine
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Cinnarizine is indicated orally as tablets of 25 and 75mg for the treatment of vertigo, tinnitus, hearing loss and nausea associated with Ménière's syndrome. It has a local anaesthetic effect in addition to its ability  to manage cerebrovascular insufficiency, cases of memory reduction and migraine. However, Cinnarizine is highly metabolized primarily by the liver. The present study aims to develop an aural Cinnarizine mucoadhesive transfersomal gel that overcomes the liver first pass metabolic effect. The gel form provides a targeted and suitable residence of the Cinnarizine Transfersomes over the tympanic membrane; the elastic vesicles can pass  through the intact tympanic membrane to the middle ear then into the systemic circulation. The work in this thesis is divided into three chapters, namely: Chapter I: Formulation and evaluation of Cinnarizine nano- Transfersomes. Chapter II: Formulation and evaluation of Cinnarizine Transfersomes into aural mucoadhesive gel delivery systems. Chapter III: A Pharmacokinetic study of Cinnarizine aural  transfersomal gel on rabbits.
UR  - http://172.23.153.220/th.pdf
ER  -