TY  - BOOK
AU  - Badr Ali Nosehy Elshamy
AU  - Bassant Salah Meligy , 
AU  - Elshimaa Salah Ahmed , 
AU  - Mona Mohey Eldin Abdelhahaleem , 
TI  - Zinc level in pediatric critical illness / 
PY  - 2020///
CY  - Cairo : 
PB  - Badr Ali Nosehy Elshamy , 
KW  - Critically ill
KW  - Sepsis
KW  - Zinc
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: In critically ill patients, there are reduced stores of antioxidants, which are associated with increased organ failure and even higher mortality. Trace elements, especially zinc (Zn) and selenium, are the cornerstone of the antioxidant defense in acute systemic inflammatory response syndrome. The aim of our study is to detect the serum level of zinc as important immunomodulator in critically ill children and to investigate the relationship between Zn and the severity of illness, Sepsis and Mortality.Patient and Methods: The study was conducted on 50 critically ill children within 72 hours of intensive care unit admission with PRISMIII score more than 5, and 50 children of intensive care unit admissions as controls with PRISMIII score less than 5. Blood samples were collected from the two groups for zinc level measurement. Results: The study yielded the following results: Zn level was found to be decreased in critically ill children compared to control group (P value<.0001), and these levels were inversely correlated with pediatric logistic mortality scores. Zinc level was decreased in patients with sepsis and in patients with multiple organ failure (P value<.0001). Conclusion: The study concludes: zinc supplementation is important for a critically ill children and its deficiency might play role in the pathogenesis of severe sepsis
ER  -