TY  - BOOK
AU  - Sanaa Abdelrasoul Khalil
AU  - Dina Hesham Ahmed , 
AU  - Mohammed Elbasel Hegazy , 
AU  - Mohammed Momtaz Mohammed , 
TI  - Serum copeptin and high sensitivity c-reactive protein for differentiating bacterial infection from disease activity in patients with lupus nephritis / 
PY  - 2020///
CY  - Cairo : 
PB  - Sanaa Abdelrasoul Khalil , 
KW  - Bacterial infection
KW  - Lupus activity
KW  - Lupus nephritis
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Internal Medicine; Issued also as CD
N2  - Background: Clinical features of infection may sometimes be quite similar to those of active lupus, making it difficult to detect the existence of infection. Several biological markers have been studied for differentiation of infection from disease activity in Systemic Lupus Erythematosus (SLE) patients with discrepant results.objectives: The aim of this study was to evaluate the role of serum copeptin and hs-CRP in differentiating bacterial infections from disease activity in lupus nephritis patients. subjects and methods: Our patients were divided into two groups: group )1 (forty four patients with active lupus nephritis, diagnosed according to the American College of Rheumatology (ACR) classification criteria for SLE and ultrasounography guided renal biopsy, group (2) forty four patients with active lupus nephritis admitted with proven bacterial infection. The diagnosis of a bacterial infection was based on the presence of a positive pathogen test from various specimens (blood, sputum, pus, and urine), clear evidence of infection (pneumonic infiltration on computed tomography [CT], or evidence of an abscess on ultrasound, CT or MRI), and clear clinical signs correlating with infection. A positive response to the standard antibiotic therapy was also used to support the diagnosis of bacterial infection. SLEDAI was used for assesment of activity. Measurements of hs-CRP and copeptin were performed. Sensitivity and specificity were calculated for both biomarkers. results: The median age of the study population was 28.5 years; 92 % of the patients were females. Bacterial infections were confirmed in 44 cases (17 culture-proven UTI, 16 Respiratory Tract Infections; 9 proven by cultures and 7 by CT, 10 culture-proven bloodstream infections, and 1 culture-proven skin infection. Hs-CRP was elevated in active lupus nephritis patients with proven bacterial infection (mean 4 mg/L) vs active lupus nephritis patients (mean 1.91 mg/L); p < 0.001.While serum copeptin was elevated in both active lupus nephritis patients with proven bacterial infection (mean 88.17 ng/L) and active lupus nephritis patients (mean 80.59 ng/L); p < 0.049
ER  -