Engy Atef Boshra <br/><br/>
Assessment of serum citrulline level and its correlation to nutritional status and adherence to gluten free diet in a cohort of Egyptian Celiac Disease Patients /  
 قياس نسبة السترولين بالدم لمجموعة من المرضى المصريين المصابين بمرض السيلياك وعلاقتها بالحالة الغذائية للمرضى و تاثير الطعام الخالى من الغلوتين   
Engy Atef Boshra ; Supervised Ayman Emil Eskander , Shrouk Moataz Sayed , Radwa Marawan Abdelhalim 
 - Cairo :   Engy Atef Boshra ,   2020 
 - 170 P. :   charts , facsmilies ;   25cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics 
<br/><br/> Background and aim:  Celiac disease (CD) is a chronic inflammatory bowel condition triggered by gluten ingestion. It characterized predominately by intestinal symptoms that lead to malabsorption syndrome and stunted growth in young children. The only significant treatment is lifelong gluten free diet (GFD). The aim of the study is assessment of prevalence of malnutrition among CD patients and testing citrulline level and its correlation to nutritional status and adherence to gluten free diet in a cohort of Egyptian  CD patients  Methods: This is a case control cross sectional study was conducted at Pediatric Gastroenterology unit, Cairo University Pediatric Hospital. Sixty patients with CD with or without history of gluten free diet less than 6 months duration and other sixty children age- and sex-matched controls were enrolled. Clinical and laboratory data were compared between the two groups. Serum citrulline level was analyzed in all patients.  Results: Our study revealed that the results of weight z-score, height z-score, TSF and MUAC were shown significant lower values in case group in comparison to control groups. According to GOMEZ classification, protein energy malnutrition represented 53.3% (64/120) of all the studied children. The frequency was highly significant among CD patients. CD patients showed a significantly lower citrulline levels with a mean (SD)  785.50 ± 381.33 pg/ml, compared to higher levels in healthy controls (mean 1831.81 ± 897.99pg/ml).                                                                                                                                       
<br/><br/>
<br/><br/><label>Subjects--Index Terms: </label>Celiac disease Malabsorption syndrome Short stature