TY  - BOOK
AU  - Maha Ahmed Mahmoud Farag
AU  - Doaa Ahmed Abdelfadeel , 
AU  - Maha Fadel Mohamed , 
TI  - Topical photodynamic therapy of ehrlich solid tumors using TMPyP loaded in ultradeformable nanopharmaceuticals / 
PY  - 2020///
CY  - Cairo : 
PB  - Maha Ahmed Mahmoud Farag , 
KW  - Nanopharmaceuticals
KW  - TMPyP
KW  - Topical photodynamic therapy
N1  - Thesis (M.Sc.) - Cairo University - National Institute of Laser Enhanced Science - Department of Laser Applicatin in Medical; Issued also as CD
N2  - Photodynamic therapy is a clinically approved procedure for the treatment of neoplastic and other non-malignant diseases. Meso-tetrakis(N-methyl-4- pyridyl)porphyrin (TMPyP) is a photosensitizing agent which has been used in many applications. However, the use of TMPyP topically is limited due to its hydrophilicity. To overcome this problem,TMPyP was loaded in ethosomes.Three ethosomal formulae (A), (B) and (C) were prepared and characterized. Preparation (A) was chosen to be used in the in vitro and in vivo study, having the greatest encapsulation efficiency, the smallest size and the highest cumulative release percentage.The results of in vitro permeation study revealed that the ethosomal TMPyP was superior to the drug in the free form with permeation flux (3.92 og cm⁻²h⁻¹). In the in vivo animal study done on Swiss albino mice, after 19 days of tumor implantation, the group treated with the ethosomal preparation showed significantly smaller tumor size (143.28 ± 13.2 mm³) compared to the group treated with the free TMPyP (219 ± 11.9 mm³). It showed also significant longer survival time (21 days) compared to that treated with the free drug (18.2± 1.2 days). Based on the obtained results, transdermal delivery of TMPyP was potentiated by incorporating it in ethosomes
ER  -