TY  - BOOK
AU  - Mohammad Ahmad Saleh Bashar
AU  - Azza Saleh Radwan , 
AU  - Mohamed Hafez Elsaied Hafez , 
AU  - Sohaila Hussein Omar , 
TI  - Evaluating the effect of desflurane versus sevoflurane withrecent biomarkers  of renal and hepatic function in laparoscopic cholecystecomy patients / 
PY  - 2020///
CY  - Cairo : 
PB  - Mohammad Ahmad Saleh Bashar , 
KW  - Desflurane
KW  - Laparoscopic cholecystecomy patients
KW  - Sevoflurane
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Anaesthesia; Issued also as CD
N2  - Background:  Exposure to inhalational anesthetics is associated with hepatic and renal changes. aim: To compare sevoflurane (S) versus desflurane (D) with more sensitive and specific biomarkers of hepatic and renal functions in patients undergoing elective laparoscopic cholecystectomy.  patients and methods: A prospective randomized study with 70 patients (D, n = 35 and S, n = 35). Neutrophil Gelatinase Associated Lipocalin, Cystatin-C, Arginase, liver (AST, ALT) and kidney function tests (BUN and creatinine) were assayed.results:  High serum NGAL levels suggest the possibility of subclinical renal injury in the desflurane group, but with no renal clinical adverse effects.The specific biomarkers showed early elevations at 1 hour postoperatively for cystatin and 1 to 6 hours postoperatively with arginase in both groups, with no adverse clinical renal or liver effects. conclusion:This study confirmed that sevoflurane and desflurane provide safe anesthetic profiles regarding renal and hepatic integrity during limited duration laparoscopic procedures. Sevoflurane and desflurane had no adverse clinical effects in these patients undergoing laparoscopic cholecystecomy. Wide scale studies comprising larger numbers of patients should be performed to assess the microscopic effects on hepatic and renal integrity using sevoflurane and desflurane during longer periods of exposure to pneumoperitoneum and volatile anesthetics
ER  -