Synthesis of some novel bis- and multi-armed heterocycles /
تشييد بعض الحلقات غير المتجانسة الثنائية و عديدة الأزرع المتماثلة الجديده
Hadeer Mohamed Diab Elhosseny ; Supervised Ahmed Helmy Mahmoud Elwahy , Ismail Abdelshafy Abdelhamid , Moustafa Elsayed Ahmed
- Cairo : Hadeer Mohamed Diab Elhosseny , 2021
- 153 P. : charts ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Organic Chemistry
Part 1: A synthesis of novel star-shaped compounds based on s-triazine core and linked to hexahydroacridinediones, pyrimido[4,5-b]quinolones, 1H-isoquinolino[2,1-a] quinolines, tetrahydro-4H-chromenes, dihydropyrano[2,3-c]pyrazoles, thiazole, or benzothiazole as new hybrid molecules through Michael and Hantzsch reactions is reported. For this purpose, the 2,4,6-tris(4-formylphenoxy)benzaldehyde was used as a versatile precursor. diones),-4,6-quinoline] b-(tetrahydropyrimido[4,5bis(sulfanediyl)bisnovel A synthesis of Part 2:5, as novel hybrid molecules -moieties at position oxindole-spirocycliclinked to aryl, heteroaryl, and was utilized as one)-)H4(1-aminopyrimidin-(6bis(sulfanediyl))bis diyl-1,4-(Butane-2,2'was reported. a precursor to our target compounds via a multicomponent reaction with two equivalents of both of the appropriate aldehyde and dimedone. The target compounds were alternatively obtained by bis-(alkylation) of the appropriate 5-aryl-2-thioxohexahydropyrimido [4,5-b]quinoline-4,6-dione with 1,4-dibromobutane in moderate basic medium. :Part 3 A novel series of bis(sulfanediyl)bis(tetrahydropyrimido[4,5-b]quinoline-4,6-diones) which are linked to benzene, pyridine, or thieno[4,5-d]thiophene cores was prepared utilizing bis(sulfanediyl))bis(6-aminopyrimidin-4(1H)-ones) as precursors. The target molecules were alternatively prepared via the bis-alkylation reactions of the appropriate 5-aryl-2-thioxohexahydro pyrimido[4,5-b] quinoline-4,6-dione with the corresponding dibromo compounds