TY  - BOOK
AU  - Shaimaa Ali Ali Radwan Moustafa
AU  - Aliaa Nabil Elmeshad , 
AU  - Raguia Aly Shoukri , 
TI  - Utilization of a nanocarrier as a feasible tool for liver targeting of a certain drug / 
PY  - 2021///
CY  - Cairo : 
PB  - Shaimaa Ali Ali Radwan Moustafa , 
KW  - Activated hepatic stellate cells (aHSCs)
KW  - Gallic acid (GA)
KW  - Liver fibrosis
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmaceutics; Issued also as CD
N2  - Gallic acid (GA) is characterized by its protective properties towards induced apoptosis in tumor cells, carbon tetrachloride induced liver injury and lung fibroblasts. It has the ability to hinder the proliferation of activated hepatic stellate cells (aHSCs) and control progression of liver fibrosis. However, the hydrophilic properties of GA hindered its entrapment in different vesicles formulations due to its fast partitioning with the surrounding aqueous media. Moreover, GA is poorly absorbed and rapidly metabolized leading to faster elimination and shorter peak plasma concentration and hence, diminished bioavailability. The present study aims to encapsulate GA into different nanocarrier systems for the passive and active targeting of GA to aHSCs for the effective treatment of liver fibrosis
ER  -