TY  - BOOK
AU  - Asmaa Ahmed Gomaa Mohamed
AU  - Azza Sayed Mohamed Awad , 
AU  - Dalaal Moustafa Abdallah , 
AU  - Hanan Salah Eldin Elabhar , 
TI  - Possible neuroprotective effect of prasugrel on global cerebral ischemia/reperfusion model in rats / 
PY  - 2021///
CY  - Cairo : 
PB  - Asmaa Ahmed Gomaa Mohamed , 
KW  - Global cerebral
KW  - Neuroprotective
KW  - Prasugrel
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology; Issued also as CD
N2  - The beneficial role of prasugrel, a P2Y12 receptor blocker, in several neurointerventional procedures has been reviewed clinically. Beyond its antiplatelet capacity, the potential neuroprotective mechanisms of prasugrel are poorly addressed experimentally. Relevant to the imbalance between neuro-inflammation and neuroprotective pathways in cerebral ischemia/reperfusion (I/R), our study evaluated the anti-ischemic potential of prasugrel treatment through tackling novel targets. Male Wistar rats were allocated into 2 sets; set 1 (I/R 60min/3days) to assess the neurological deficits/biochemical impact of prasugrel and set 2 (I/R 60min/5days) for evaluating short memory/morphological/immunoreactive changes. Each set comprised 4 groups designated as sham, sham + prasugrel, I/R, and I/R + prasugrel. Post-administration of prasugrel for 3 and 5 days reduced neurological deficit scores and improved the spontaneous activity/short term spatial memory using the Y-maze paradigm. On the molecular level, prasugrel turned off SUMO2/3-inhibitory kappa (Im) BÜ, Ubc9 and nuclear factor kappa (NF-m) B. Besides, it inhibited malondialdehyde (MDA) and inactivated astrocytes by downregulating the glial fibrillary acidic protein (GFAP) hippocampal immune-expression
UR  - http://172.23.153.220/th.pdf
ER  -