Pharmacognostical study and tissue culture of certain araucaria species grown in Egypt /
دراسة عقاقيرية و زراعة النسجة لبعض أنواع جنس الأروكاريا التى تنمو فى مصر
Dalia Galal Eldin Ahmed Abdelaaal Elkolobby ; Supervised Seham Salah Eldin Elhawary , Mohamed Abdelatty Rabeh , Essam Mostafa Abdelkadder
- Cairo : Dalia Galal Eldin Ahmed Abdelaaal Elkolobby , 2021
- 270 P. : charts , facsimiles ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of Pharmacy - Department of Pharmacognosy
Araucaria bidwillii Hooker., Araucaria cunninghamii Aiton ex D. Don and Araucaria heterophylla (Salisburry) Franco, are ornamental plants in Araucariaceae family. The aim of this study was to investigate these species from the phytochemical and biological points of view. DNA fingerprinting was done for identification of the three plants. Biological studies were performed on the alcoholic extracts of the three species. Invitro antiaging, anti-Alzheimer, antidiabetic, antioxidant, anti-inflammatory, cytotoxic and antimicrobial activities were estimated for the three species. A. cunninghamii and A. bidwillii showed promising anti-inflammatory results. In addition phytochemical study, including phytochemical screening, investigation of phenolic content, metabolomics analysis by LC/MS/MS was performed using negative mode comparing the three species resulting in identification of twenty two compounds and GC-MS analysis of the head space volatile constituents was carried for A. cunninghamiiresulted in identification of 31 volatile constituents whereas (-)-Ü-Pinene and p-Menthan-1-ol represented 32.95% and 25.02% respectively. Molecular docking studies were done for further investigation of possible targets involved in the biological action of the three species according to the dereplicated and the studies showed a significant low binding energies of amentoflavone and bilobetin glucoside against SARS-CoV-2. secondary metabolites against COVID-19 and other various activities