TY  - BOOK
AU  - Lamiaa Alsayed Awad Yadam
AU  - Amal Mostafa Hagras , 
AU  - Doaa Mohamed Salah , 
AU  - Rasha Essam Eldin Abdelaziz Galal , 
TI  - Urine periostin as a biomarker of pediatric chronic renal allograft nephropathy / 
PY  - 2021///
CY  - Cairo : 
PB  - Lamiaa Alsayed Awad Yadam , 
KW  - Acute rejection; adherence
KW  - Chronic graft injury
KW  - Dialysis duration
N1  - Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics; Issued also as CD
N2  - Background: Periostin is an adhesion molecule that was reported to have renal histopathologic expression patterns and effect suggesting that it may be a biomarker of chronic allograft nephropathy (CAN) in kidney transplant recipients (KTRs). Objectives: The aim of this study was to evaluate the role of urinary periostin as a marker of CAN in pediatric KTRs and to study the different potentially modifiable risk factors contributing to the development of CAN. Methods: The study included 52 pediatric KTRs (21 patients with CAN and 31 patients without CAN). Urine samples for periostin levels were assessed by ELISA technique. Thirty age/ sex matched healthy controls served as reference for periostin values. Results: No difference in periostin was detected between patients and controls (p= 0.151). Also no difference in urine perisotin was detected between CAN and non CAN patients (p= 0.602). CAN patients were older in age at assessment, had longer pre-transplantation dialysis duration and post-transplantation follow up duration than non CAN patients (p=0.032, 0.023 and 0.004 respectively). CAN patients were more non adherence to medications (40.7% versus 8% with p=0.006), and experienced more frequent acute rejection (AR) episodes (p<0.05) than non CAN patients
UR  - http://172.23.153.220/th.pdf
ER  -