Basant Ahmed Abdelalim Ahmed <br/><br/>
Diagnostic implication of urinary 8-hydroxy-2-eoxyguanosine (8-OHdG) as a novel biomarker for early prediction of diabetic kidney disease in adolescents with type 1 diabetes mellitus /  
 الدلالة التشخيصية ل 8-هيدروكسى-2-دى أوكسى جوانوزين فى البول  كمؤشر حيوى جديد للتنبؤ المبكر عن مرض الكلى السكري لدى البالغين  المصابين بالسكرى من النوع الأول 
Basant Ahmed Abdelalim Ahmed ; Supervised Mona Mamdouh Abdelghafoor Hassan , Rasha Essam Eldin Galal , Laila Ahmed Rashed Ismail 
 - Cairo :   Basant Ahmed Abdelalim Ahmed ,   2021 
 - 119 :   charts ;   25cm  
<br/><br/>Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics  
<br/><br/> Introduction: Diabetic microvascular complications (DMCs) involve nephropathy, retinopathy, and neuropathy. Diabetic kidney disease (DKD) is the most frequent and serious complication. It is the main cause of chronic kidney disease, which begins with normoalbuminuria and progresses to microalbuminuria, macroalbuminuria, and finally end stage kidney disease.The severity of DKD is assessed by the amount of albuminuria present, but it lacks the sensitivity and specificity needed to detect an early stage of DKD, so other biomarkers are needed. One of these biomarkers is urinary 8-Hydroxy-2-Deoxyguanosine (8-OHdG). Objectives:The aim of this study is to assess the sensitivity and specificity of urinary 8-OHdG as a novel biomarker for early detection of DKD in adolescents with type 1 diabetes mellitus (T1DM).  Methods:The study included 91 participants; 64 adolescents with T1DM following at the DEMPU at Children's Hospital of Cairo University, and 27 healthy adolescents who were recruited as a control group from subjects accompanying their parents visiting sick siblings and relatives in Children's Hospital of Cairo University.T1DM patients were classified according to their urinary albumin/creatinine ratio (UACR) resultsinto 3 groups: group A (normoalbuminuria), group B (persistent microalbuminuria), and group C (recurrent microalbuminuria). A questionnaire was taken from T1DM patients; including: chronological age, gender, age at onset of T1DM, insulin dose, types, and regimen, use of angiotensin converting enzyme inhibitors (ACEIs), history suggestive of other diabetic complications, and history of other diseases (such as cardiovascular, renal, and urinary tract, hepatic, respiratory, neurodegenerative, and psychiatric diseases). Blood pressure and anthropometric measurements were performed for every participant. Laboratory tests were requested within 3 months of T1DM patient recruitment and included: glycosylated haemoglobin (HbA1c),full lipid profile (serum total cholesterol, serum triglycerides, serum low density lipoprotein-cholesterol, and serum high density lipoprotein-cholesterol), kidney function tests (serum creatinine and urea), and UACR 
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<br/><br/><label>Subjects--Topical Terms: </label><br/>Diabetic kidney disease
<br/><br/><label>Subjects--Index Terms: </label>Diabetic kidney disease  Diabetic microvascular complications  Type 1 diabetes mellitus