Effect of some chemopreventive agents on galactose induced cataract in rats /
تأثير بعض المواد للوقاية من إعتام العدسة المحدث بالجالاكتوز فى الجرذان
Hager Abdalhamid Mohamed Abdalhamid ; Supervised Nermin Abdelhamid Sadik , Noha Ahmed Elboghdady , Nesreen Nabil Omar
- Cairo : Hager Abdalhamid Mohamed Abdalhmid , 2022
- 128 P. : charts , facsimiles ; 25cm
Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry
Cataract is the principal cause of blindness.The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of ten rats. Control group was fed with normal diet; group 2 rats were fed with galactose diet (50%); groups 3, 4 rats were fed with galactose diet concurrently with either esculetin (50 mg/kg BW) or idebenone (100 mg/kg BW), for 20 days.The study revealed that esculetin and idebenone significantly reduced the elevated levels of Bax/Bcl-2 ratio, malondialdehyde, and DNA fragmentation and increased total antioxidant capacity level in lenses compared to the cataract-induced group. Only esculetin decreased AR, galactitol, and advanced glycated end products levels in lenses. Histopathological examinations supported the biochemical findings. Esculetin and idebenone may have chemopreventive effects for sugar cataract