TY  - BOOK
AU  - Hager Abdalhamid Mohamed Abdalhamid
AU  - Nermin Abdelhamid Sadik , 
AU  - Nesreen Nabil Omar , 
AU  - Noha Ahmed Elboghdady , 
TI  - Effect of some chemopreventive agents on galactose induced cataract in rats / 
PY  - 2022///
CY  - Cairo : 
PB  - Hager Abdalhamid Mohamed Abdalhmid , 
KW  - Galactose
KW  - Aldose reductase
KW  - Cataract
KW  - Esculetin
N1  - Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Biochemistry; Issued also as CD
N2  - Cataract is the principal cause of blindness.The enzyme, aldose reductase (AR) is a key player in polyol pathway. Buildup of polyols and oxidative stress are the main causes of cataractogenesis. This study investigated the cytoprotective properties of esculetin and idebenone in galactose-induced cataract. Rats were partitioned into four groups each of ten rats. Control group was fed with normal diet; group 2 rats were fed with galactose diet (50%); groups 3, 4 rats were fed with galactose diet concurrently with either esculetin (50 mg/kg BW) or idebenone (100 mg/kg BW), for 20 days.The study revealed that esculetin and idebenone significantly reduced the elevated levels of Bax/Bcl-2 ratio, malondialdehyde, and DNA fragmentation and increased total antioxidant capacity level in lenses compared to the cataract-induced group. Only esculetin decreased AR, galactitol, and advanced glycated end products levels in lenses. Histopathological examinations supported the biochemical findings. Esculetin and idebenone may have chemopreventive effects for sugar cataract
UR  - http://172.23.153.220/th.pdf
ER  -