Efficacy Of Intralesional Injection Of Autologous Platelet Rich Plasma Versus Intralesional Injection Of Corticosteroids On Pain Relief And Ulcers Healing In Patients With Erosive Oral Lichen Planus : Randomized Clinical Trial /
دراسة سريرية عشوائية: مقارنة تأثير الحقن الموضعي للبلازما الغنية بالصفيحات الذاتية بالحقن الموضعي للستيرويدات على تخفيف الألم وشفاء القرح لدى مرضى الحزاز الفموي المنبسط التقرحي
Abdelhameed Hamid Mohammad Hijazi ; Supervised Soheir Mohamed Gaafar , Wesam Abdelmoneim Mohamad Ahmad
- Cairo : Abdelhameed Hamid Mohammad Hijazi , 2021
- 140 P . : charts , photographs ; 25cm
Thesis (Ph.D.) - Cairo University - Faculty of oral and dental medicine - Department of Periodontology
Aim: to evaluate the clinical efficacy of intralesional platelet rich plasma (PRP) injections compared to intralesional triamcinolone acetonide (TA) injections in the treatment of erosive oral lichen planus (EOLP) Methodology: 20 patients with EOLP were randomly assigned either to PRP or TA group, they received weekly intralesional injections for 4 weeks, and then followed up for 3 months on regular visits every 2 weeks. Pain score using Numerical pain score and clinical score were recorded each visit for all patients and remission score at the end of trial was recorded. Results: both PRP and TA groups showed significant improvement in the clinical parameters (pain and clinical score) p =0.001, and 80% of patients in PRP group showed complete remission compared to 70% in TA group. Where there is no statistical significance when comparing the two groups in pain score, clinical score or remission. Conclusions: PRP injections can be effective as a single treatment modality for EOLP.