TY  - GEN
AU  - Sameera Ezzat AbouElKhair
AU  - Hussein Mostafa Khaled , 
AU  - Laila Shehata Dorgham , 
AU  - Nargis Albert Labib , 
TI  - Genetic mutation study among hepatocellular carcinoma patients : : Case control Study / 
PY  - 2006///
CY  - Cairo : 
PB  - Sameera Ezzat AbouElKhair , 
KW  - Environment interaction
KW  - Gene
KW  - Hepatocellular carcinoma
N1  - Thesis (PH.D.) - Cairo University - Faculty Of Medicine - Department Of Community Medicine; Issued also as CD
N2  - Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwideThe aim of the present study was to assess the association of mutation of specific genes : cytochrome P450 1A1 (CYP1A1) , cytochrome P450 2D6 (CYP2D6) , microsomal epoxide hydrolase (EPHX) and paraoxonase (PON1) and environmental exposures on the risk of HCC in EgyptA case - control study was conducted on 459 subjects with confirmed HCC recruited from the National Cancer Institute , Cairo University , Egypt , and 634 controls recruited from orthopedic department , Cairo University Hospital , Egypt and from two villages in Menoufiya governoratePatients who agreed to participate signed a consent form , answered a questionnaire and gave a blood sample for hepatitis virus and genetic testingPON1 polymorphism was inversely related to HCC , OR was 07 (95in hundred CI : 05 - 11) EPHX1 Slow activity was significantly associated with HCC (OR= 15 , 95in hundred CI : 11 - 22) compared to high metabolizers after adjustment with age , sex , current HCV and current HBV infectionCYP1A1 mutation was not associated with HCC in the present study (OR= 20 , 95in hundred CI : 04 - 102) CYP2D6 extensive metabolizers was associated with HCC (OR= 18 , 95in hundred CI : 11 - 30) compared to poor metabolizersNo significant interaction between smoking or pesticides exposure and the studied genesAs expected , the strongest risk factors for HCC in this study were HCV RNA (OR = 11 - 13) and current HBV infection (OR = 6 - 9) This study therefore suggests that mutation in the studies genes are additive risk factors to current HCV and HBV infection
UR  - http://172.23.153.220/th.pdf
ER  -