Ahmed Anwar Sayed Mohamed <br/><br/>
Molecular study of multiple tumor suppressor gene and epidermal growth factor receptor expressions in breast carcinomas /  
 دراسة جزيئيه للتعرف على الجين المتعدد و المثبط و مستقبل عامل النمو الجلدى فى اورام الثدي 
Ahmed Anwar Sayed Mohamed ; Supervised Sanaa Osman Abdallah , Afaf Abd El Halim Abd El Khalek , Motawa Eisa ElHousseini 
 - Cairo :   Ahmed Anwar Sayed Mohamed ,   2005 
 - 137p :   ill ;   30cm 
<br/><br/>Thesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry 
<br/><br/> expression has been reported in cancer cell lines and in certain malignant neoplasmThis gene encodes a protein that function as a negative cell cycle regulator at G1 - S checkpointOverexpression of EGFR has been shown in human cancer and could serve as a target for diagnosis and therapy for malignancyThis study was conducted on 14 benign breast tissues taken as control and 36 breast cancer patientsRT - PCR and ELISA techniques were used for detection of p16 and EGFR respectivelyFurthermore a significant increase of p16 expression was observed in benign breast tissue compared to malignant breast one p< 0001Also , a significant increase of p16 expression was found in low grade , negative lymph node and in histological subtype ILђC 
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<br/><br/><label>Subjects--Index Terms: </label>Carcinomas expressions