TY  - GEN
AU  - Ahmed Anwar Sayed Mohamed
AU  - Afaf Abd El Halim Abd El Khalek , 
AU  - Motawa Eesa El Housseini , 
AU  - Sanaa Osman Abdallah , 
TI  - Molecular study of multiple tumor suppressor gene and epidermal growth factor receptor expressions in breast carcinomas / 
PY  - 2005///
CY  - Cairo : 
PB  - Ahmed Anwar Sayed Mohamed , 
KW  - Carcinomas
KW  - expressions
N1  - Thesis (PH.D.) - Cairo University - Faculty Of Science - Department Of Biochemistry; Issued also as CD
N2  - expression has been reported in cancer cell lines and in certain malignant neoplasmThis gene encodes a protein that function as a negative cell cycle regulator at G1 - S checkpointOverexpression of EGFR has been shown in human cancer and could serve as a target for diagnosis and therapy for malignancyThis study was conducted on 14 benign breast tissues taken as control and 36 breast cancer patientsRT - PCR and ELISA techniques were used for detection of p16 and EGFR respectivelyFurthermore a significant increase of p16 expression was observed in benign breast tissue compared to malignant breast one p< 0001Also , a significant increase of p16 expression was found in low grade , negative lymph node and in histological subtype IL{u00B4}ђ{u008ѕ}C
ER  -