Mona Hassan Farouk Montash <br/><br/>
Immunobiological activity of synthetic peptides from schistosoma mansoni glyceraldehyde - 3 - phosphate dehydrogenase /  
 النشاط المناعي - البيولوجى للبيبتيدات المصنعة من انزيم جلسرالدهايد 3 - فوسفات ديهايدروجينا لدودة بلهارسيا المستقيم 
Mona Hassan Farouk Montash ; supervised Victorine Bishara , Rashika ElRidi , Gamil Amin 
 - Cairo :   Mona Hassan Farouk Montash ,   2004 
 - 126 Leaves :   ill ;   30cm 
<br/><br/>Thesis (M.Sc.) - Cairo University - Faculty Of Science - Department Of Biochemistry 
<br/><br/> SG3PDH is a candidate vaccine for human schistosomiasisSix synthetic peptides were selected based on lowest homology to the human enzyme and named A , B1 , B , C , D and EImmunization of BALB / c mice with peptide A , B , C or E inducedweak cellular and humoral immune responses , whereas immunization with peptide B1 or D elicited strong immune responses that were protective to the challenge worms , not the hostTetrameric constructs containing 2 copies of 2 different peptides (D - MAP) greatly increased the immunogenicity of the peptides , Anti - D - MAP A - B immune responses were associated with significant (P < 005) decrease in worm and egg burdenD - MAP B1 - C caused no significant changes in challenge worm parametersImmunization with D - MAP D - E elicited increase in the challenge worm burden and decrease in worm fertilityThese results were discussed in relation to the variability in the nature and outcome of immune responses for each SG3PDH - derived peptide , and the neutralization of their often opposing effects in the D - MAP construct 
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<br/><br/><label>Subjects--Index Terms: </label>Immunobiological activity Mansoni Schistosoma Synthetic peptides