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Study of genetic variations in apoptotic genes and hormonal level alterations in hepatitis C patients / Ahmed Abdrabou Abdrabou Mohamed ; Supervised Mervat Sayed Mohamed , Olfat Gamil Shaker , Emad Fawzy Eskander

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Ahmed Abdrabou Abdrabou Mohamed , 2015Description: 195 P. : charts ; 25cmOther title:
  • دراسة التغييرات الوراثية فى جينات عملية موت الخلية المبرمج و تغييرات المستوى الهرمونى فى مرضى الإلتهاب الكبدى سى [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry Summary: The hepatitis C virus (HCV), the main cause of morbidity and mortality, is endemic worldwide. HCV is most common in underdeveloped nations, with the highest prevalence rates in Egypt. The dual therapy with pegylated-interferon - Ü2b plus ribavirin has markedly improved the clinical outcome of HCV. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg / Pro and -670 A / G respectively on HCV genotype - 4a susceptibility and treatment response. Two hundred and forty volunteers were enrolled in this study and divided into two major groups; the first group was 160 HCV infected patients group and the second group was 80 healthy controls group. HCV patients were sub-divided into two sub - groups; 86 sustained virological responders sub - group and 74 non-responders sub - group
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2015.Ah.S (Browse shelf(Opens below)) Not for loan 01010110066799000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.12.02.Ph.D.2015.Ah.S (Browse shelf(Opens below)) 66799.CD Not for loan 01020110066799000

Thesis (Ph.D.) - Cairo University - Faculty of Science - Department of Biochemistry

The hepatitis C virus (HCV), the main cause of morbidity and mortality, is endemic worldwide. HCV is most common in underdeveloped nations, with the highest prevalence rates in Egypt. The dual therapy with pegylated-interferon - Ü2b plus ribavirin has markedly improved the clinical outcome of HCV. P53 induces the expression of Fas for triggering apoptosis; an important mechanism for limiting viral replication. This study aims at investigating the impact of P53 rs 1042522 and Fas rs 1800682 genetic polymorphisms at 72 Arg / Pro and -670 A / G respectively on HCV genotype - 4a susceptibility and treatment response. Two hundred and forty volunteers were enrolled in this study and divided into two major groups; the first group was 160 HCV infected patients group and the second group was 80 healthy controls group. HCV patients were sub-divided into two sub - groups; 86 sustained virological responders sub - group and 74 non-responders sub - group

Issued also as CD

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