Chemotherapy as an adjuvant to radiotherapy in treatment of retinoblastoma / Ameera Hamdy Mohammad Ahmed ; Supervised Hany Salah Eldin Hamza , Mohamed Mostafa Lotayef , Amany Aly Lotfy

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Ophthalmology

Retinoblastoma is the most common primary intraocular malignancy of childhood. A potentially curable cancer, its treatment has improved significantly over the last few decades. Various studies show that while enucleation remains the standard of care for advanced intraocular tumours, conservative modalities that can result in globe salvage and preservation of useful vision are being increasingly employed. Such modalities include systemic chemotherapy, focal consolidation with transpupillary thermotherapy, laser photocoagulation and cryotherapy, plaque brachytherapy, and delivery of local chemotherapy using subconjunctival, sub-tenon, or intra-arterial routes. When used alone or in combination, these treatment modalities can help in avoidance of external beam radiotherapy or enucleation, thus reducing the potential for long-term side effects, while salvaging useful vision. Radioactive plaque brachytherapy has an established role in selected patients with intraocular retinoblastoma

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