header
Image from OpenLibrary

Study of the possible role of cAMP and KATP channels in atorvastatin-induced hepatotoxicity / Engy Ali Elsayed Mansour ; Supervised Hesham Aly Salem , Sherifa Kamal Ahmed , Suzan Mohamed Mansour

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Engy Ali Elsayed Mansour , 2019Description: 113 P. : charts , facsimiles ; 25cmOther title:
  • دراسة الدور المحتمل لادينوسين احادى الفوسفات الحلقي وقنوات البوتاسيوم ادينوسين ثلاثى الفوسفات على التسمم الكبدي الناجم عن اتورفاستاتين [Added title page title]
Subject(s): Available additional physical forms:
  • Issued also as CD
Dissertation note: Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology Summary: Atorvastatin (ATO), a 3-hydroxy-3-methylglutryl-CoA reductase inhibitor, is used widely for treatment of hypercholesterolemia and hypertriglyceridemia. The full clinical utility of ATO has now been somehow limited because of ATO-associated several acute and chronic side effects.The aim of the present work was to investigate the possible mechanism by which cyclic adenosine monophosphate (cAMP) induction or KATP channel opening might affect ATO-induced hepatotoxicity.1- Preliminary study: to determine the most appropriate hepatotoxic regimen (dose and duration) of ATO,depending on measuring alanine transaminase (ALT) and aspartate transaminase (AST) in addition to histopathological liver examination, was performed
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Home library Call number Copy number Status Date due Barcode
Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2019.En.S (Browse shelf(Opens below)) Not for loan 01010110079340000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.08.09.M.Sc.2019.En.S (Browse shelf(Opens below)) 79340.CD Not for loan 01020110079340000

Thesis (M.Sc.) - Cairo University - Faculty of Pharmacy - Department of Pharmacology and Toxicology

Atorvastatin (ATO), a 3-hydroxy-3-methylglutryl-CoA reductase inhibitor, is used widely for treatment of hypercholesterolemia and hypertriglyceridemia. The full clinical utility of ATO has now been somehow limited because of ATO-associated several acute and chronic side effects.The aim of the present work was to investigate the possible mechanism by which cyclic adenosine monophosphate (cAMP) induction or KATP channel opening might affect ATO-induced hepatotoxicity.1- Preliminary study: to determine the most appropriate hepatotoxic regimen (dose and duration) of ATO,depending on measuring alanine transaminase (ALT) and aspartate transaminase (AST) in addition to histopathological liver examination, was performed

Issued also as CD

There are no comments on this title.

to post a comment.