Bacteriological profile and antibiogram : With study of il6 as diagnostic marker in neonates with sepsis / Ghada Mohammed Sayed Abdelrhman ; Supervised Amira Abdelfatah Idrees , Shreif Elanwary Abdelmenam , Doaa Mohammed Gaith

Thesis (M.Sc.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Sepsis is a significant cause of morbidity and mortality in the newborn, particularly in preterm, low birth weight infants. Despite advances in neonatal care, infections remain common and sometimes lifethreatening in neonates admitted to the neonatal intensive care unit (NICU). Interleukin-6 belongs to the family of cytokines. It is one of the mediators of inflammation that are released early in the course of septic shock and is crucial in initiating the immune response. To determine the common bacterial isolates causing sepsis in neonatal intensive care unit at Elkaser Elaini Hospital and its antibiotic susceptibility pattern and the role of IL6 in the diagnosis of neonatal sepsis. This is a cross sectional study conducted on 75 neonates with suspicion of infection. Newborns were classified as aproved, probable or no infection, based on the results of cultures, chest X-rays, laboratory data and clinical signs. Grouping was done prior to measuring levels of interleukin-6. The proven sepsis group contained 32 neonates, the probable sepsis 19 neonates and not infected 24 neonates. Among the proven sepsis patients, organisms detected were klebsiella 53.1%, CONS 31.1%, staph aureus 9.4% and demonstrated high sensitivity to quinolones. Interleukin-6 was found to be statisically higher in the blood culture positive group (proven sepsis) than the blood culture negative groups (probable, non infected). klebsiella was predominant isolates followed by CONS, staph aureus with demonstrated high sensitivity to quinolones. Interleukin-6 proved to be of benefit in discriminating infected neonates from non infected ones

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