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Toll-like receptor 4 gene polymorphisms in Egyptian children with familial mediterranean fever / Hanan Tawfik Abdelaziz ; Supervised Samia Salah Eldin Mahmoud , Huda Marzouk Mohamed , Yomna Mohamed Farag

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hanan Tawfik Abdelaziz , 2019Description: 143 P. : charts ; 25cmOther title:
  • التعدد الشكلى الجينى فى المستقبل شبيه التول 4 عند الأطفال المصريين المصابين بحمى البحر المتوسط [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics Summary: Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive, disorder affecting people in the region of Mediterranean Sea. MEFV gene that encodes the pyrin protein has an influences on the inflammatory response. Toll like receptors (TLR) are a family of pattern recognition receptor that recognize pathogenic microbes and activate antimicrobial defense mechanisms. Toll like receptor 4 (TLR-4) is concerned with recognition of gram negative organism. The aim of the current study is to evaluate the presence of TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms in association with Egyptian children having FMF, furthermore its effect on disease course and severity. Methods: Seventy Egyptian children diagnosed as having FMF, together with fifty controls, Age and Sex- matched. The TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms were determined by (PCR-RFLP) analysis for all studied patients and control
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2019.Ha.T (Browse shelf(Opens below)) Not for loan 01010110078993000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.28.Ph.D.2019.Ha.T (Browse shelf(Opens below)) 78993.CD Not for loan 01020110078993000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine - Department of Pediatrics

Objective: Familial Mediterranean Fever (FMF) is an autosomal recessive, disorder affecting people in the region of Mediterranean Sea. MEFV gene that encodes the pyrin protein has an influences on the inflammatory response. Toll like receptors (TLR) are a family of pattern recognition receptor that recognize pathogenic microbes and activate antimicrobial defense mechanisms. Toll like receptor 4 (TLR-4) is concerned with recognition of gram negative organism. The aim of the current study is to evaluate the presence of TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms in association with Egyptian children having FMF, furthermore its effect on disease course and severity. Methods: Seventy Egyptian children diagnosed as having FMF, together with fifty controls, Age and Sex- matched. The TLR-4 (Asp299Gly and Thr399Ile) gene polymorphisms were determined by (PCR-RFLP) analysis for all studied patients and control

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