A novel cohort study of Chr9p21 (desert gene) genetic variants in cardiovascular patients with type-2 diabetes / Heba Ali Mohamed Shendy ; Supervised Mohamed Z. Gad , Sally Ibrahim Hassanein
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TextLanguage: English Publication details: Cairo : Heba Ali Mohamed Shendy , 2015Description: 112 Leaves : charts , photographs ; 30cmSubject(s): Online resources: Dissertation note: Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Biochemistry Summary: Cardiovascular disease is a leading cause of death worldwide. Chr9p21 locus happened to be the most robust genetic marker of CAD. The entire core of chr9p21 is covered by 'ANRIL' and lies in a region that is free from any coding proteins and therefore it is called the desert gene. Beside this region, are some protein coding genes, CDKN2A, CDKN2B. The association mechanisms for chr9p21 with atherosclerotic disease are vague but, it was suggested that ANRIL, influences the regulation of the epigenetic modification and thus modulate cardiovascular risk, as its expression is highly detected in vascular tissues related to atherosclerosis
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Thesis
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قاعة الثقاقات الاجنبية - الدور الثالث | المكتبة المركزبة الجديدة - جامعة القاهرة | Cai01.34.M.Sc.2015.He.N (Browse shelf(Opens below)) | Not for loan | 01010110072297000 |
Thesis (M.Sc.) - German University - Faculty of Postgraduate Studies and Scientific Research - Department of Biochemistry
Cardiovascular disease is a leading cause of death worldwide. Chr9p21 locus happened to be the most robust genetic marker of CAD. The entire core of chr9p21 is covered by 'ANRIL' and lies in a region that is free from any coding proteins and therefore it is called the desert gene. Beside this region, are some protein coding genes, CDKN2A, CDKN2B. The association mechanisms for chr9p21 with atherosclerotic disease are vague but, it was suggested that ANRIL, influences the regulation of the epigenetic modification and thus modulate cardiovascular risk, as its expression is highly detected in vascular tissues related to atherosclerosis
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