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Effect of delta-aminolevulinic acid dehydratase polymorphism on susceptibility to lead poisoning among lead exposed workers / Hebatalla Saad Teleb ; Supervised Mona Sobhy Siha , Lalia Ahmed Rashed , Dalia Abdelhamid Shaker

By: Contributor(s): Material type: TextTextLanguage: English Publication details: Cairo : Hebatalla Saad Teleb , 2017Description: 173 P. : charts , facsimiles ; 25cmOther title:
  • تأثير تعدد الأشكال لحمض الدلتا أمينوليفولينك النازع للماء على القابلية للتسمم بالرصاص بين العمال المعرضين للرصاص [Added title page title]
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Dissertation note: Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Industrial Occupational and Environmental Medicine Summary: Introduction:Lead is used in ammunition industry. It has been associated with several health hazards among exposed workers. Aim:The aim of this work isto obtain some insights of the distribution of e-ALAD polymorphism among lead exposed workers and their effect on some hematological and renal indices. Subjective and methods:This study was conducted on 50 lead exposed workers compared to 50 non-exposed individuals, where full history, clinical examination, and laboratory investigations in the form of: genetic study of e-ALAD gene polymorphism, blood leadlevel, CBC, serum creatinine and urea, U-e-aminolevulinic acid, U-B2-microglobulin were done. Results:Statistically significant (p<0.05) differences were found between exposed and control as regards the prevalence ofhematological, renal, GIT and neurological manifestations. Compared to the control group, urinary B2-microglobulin, urinary e-ALADH, serum urea, serum creatinine and blood lead levelwere significantly higher among exposed workers, while significantlylowerin the mean values of complete blood picture (RBCs, Hb, MCV, MCH, MCHC and PLT)
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Thesis Thesis قاعة الرسائل الجامعية - الدور الاول المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.17.Ph.D.2017.He.E (Browse shelf(Opens below)) Not for loan 01010110073750000
CD - Rom CD - Rom مخـــزن الرســائل الجـــامعية - البدروم المكتبة المركزبة الجديدة - جامعة القاهرة Cai01.11.17.Ph.D.2017.He.E (Browse shelf(Opens below)) 73750.CD Not for loan 01020110073750000

Thesis (Ph.D.) - Cairo University - Faculty of Medicine- Department of Industrial Occupational and Environmental Medicine

Introduction:Lead is used in ammunition industry. It has been associated with several health hazards among exposed workers. Aim:The aim of this work isto obtain some insights of the distribution of e-ALAD polymorphism among lead exposed workers and their effect on some hematological and renal indices. Subjective and methods:This study was conducted on 50 lead exposed workers compared to 50 non-exposed individuals, where full history, clinical examination, and laboratory investigations in the form of: genetic study of e-ALAD gene polymorphism, blood leadlevel, CBC, serum creatinine and urea, U-e-aminolevulinic acid, U-B2-microglobulin were done. Results:Statistically significant (p<0.05) differences were found between exposed and control as regards the prevalence ofhematological, renal, GIT and neurological manifestations. Compared to the control group, urinary B2-microglobulin, urinary e-ALADH, serum urea, serum creatinine and blood lead levelwere significantly higher among exposed workers, while significantlylowerin the mean values of complete blood picture (RBCs, Hb, MCV, MCH, MCHC and PLT)

Issued also as CD

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